منابع مشابه
Tumour Biology: p53 Gene Mechanisms
Tumour is a sum of genetic errors with constantly proliferating cells. Development of cancer requires altered mechanism in just one cell resulting in unlimited replication of that cell. Inspite of several genetic insults that occur there are few cells which turn neoplastic. Thus, suggesting of a very powerful protective mechanism at work. p53, a tumour suppressor gene, is cancer prophylactic fo...
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Systems biology and molecular biology can answer the same question in quite different ways, and frequently the answers given by one sub-discipline seem no answer at all to the other. For many molecular biologists, a systemslevel explanation leaves them feeling that, until the underlying molecular mechanisms are known, the approach is hopelessly superficial. For systems biologists, on the other ...
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a , b c * Stanley Nattel , Dan M. Roden , Denis Escande Department of Medicine and Research Center, Montreal Heart Institute, Department of Medicine, University of Motreal, and Department of ́ Pharmacology, McGill University, 5000 Belanger Street East, Montreal, Quebec H1T 1C8, Canada Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA Lab. Physiopath. & Ph...
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The tumor suppressor p53 is a phosphoprotein barely detectable in the nucleus of normal cells. Upon cellular stress, particularly that induced by DNA damage, p53 can arrest cell cycle progression, thus allowing the DNA to be repaired; or it can lead to apoptosis. These functions are achieved, in part, by the transactivational properties of p53, which activate a series of genes involved in cell ...
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In the history of biology, the early 1950s to the mid-1960s represent a period of landmark discoveries that led to the establishment of a new science named Molecular Biology. The discovery of the double helical structure of DNA byWatson and Crick in 1953 facilitated the formulation of specific questions related to the hottest questions of the time, gene replication and expression. Many ambitiou...
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ژورنال
عنوان ژورنال: Science
سال: 2001
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.293.5533.1223b